불소 음용수 섭취에 따른 백서 체내 알루미늄 축적억제효과
Reducing effect of systemic fluoride administration on the accumulation of aluminum in rat
류경, 이희경, 송근배, 이영은, 이가령, 김지영,
소속 상세정보
류경 ( Ryu Kyung ) - 경북대학교 치과대학 예방치과학교실
이희경 ( Lee Hee-Kyung ) - 영남대학교 의과대학 치과학교실
송근배 ( Song Keun-Bae ) - 경북대학교 치과대학 예방치과학교실 및 BK21 사업단
이영은 ( Lee Young-Eun ) - 경북대학교 치과대학 예방치과학교실 및 BK21 사업단
이가령 ( Lee Ga-Ryoung ) - 울산과학대학 치위생과
김지영 ( Kim Ji-Young ) - 울산과학대학 치위생과
KMID : 0355420070310010031
Abstract
Objectives: The aim of this study was to demonstrate the protective effect of fluoride on aluminuin distribution in tissues of rats after administration of aluminum only or combined with fluoride.
Methods: Thirty five female Spraque-Dawley rats were randomly divided into five groups(group I, 11, 111, IV and V). The first group(group I ) was feed with re-distilled water as control, the second(group 11) was intraperitoneally(1P) injected 0.69 mg A1 once a week, the third(group III) was received 1 ppm NaF, the fourth(group IV) was received 20 ppm NaF and the fifth(group V) was received 100 ppm NaF for every day with IP injected 0.69 mg Al. After 24 weeks, kidney, liver, brain and femur were extracted, respectively. Inorganic ions(aluminum, calcium, magnesium, iron) were analyzed with Inductively coupled plasma atomic emission spectrophotometer(1CP-AES).
Results: After 24 weeks, aluminum was significantly reduced at aluminum combined fluoride group(group 11, 111, TV and V) in liver, kidney, cerebmm(p ( 0.05). Contents of calcium, magnesium, CdMg ratio and iron were not remarkably changed by treating aluminum and fluoride.
Conclusion: These results demonstrated that fluoride exerted a reducing effect against distribution of aluminum by forming an inactive complexes of aluminum and fluoride.
키워드
불소; 알루미늄; 축적억제효과
aluminum; fluoride; reducing effect
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